85. Obituary – Professor Dr. Mohammad Ataur Rahman, Syed Nazrul Hasnain

88. To compare tissue Her-2/neu with serum Her-2/neu values in treatment naïve female breast cancer in Pakistan, Naheed Qadir, Jawed Altaf Baig and Sumera Abbas Khan

92. Evaluation of the antimicrobial activity of aqueous, ethanolic and methanolic extracts of Nigella sativa (kalonji) against gram positive and gram negative bacterial isolates, Ujala Nasir and Saba Irshad

97. Hepatocurative effect of aqueous leaves extracts of Negro coffee (Cochlospermum tinctorium) on carbon tetrachloride induced liver injury in rats, A. A. Adam, B. Y. Muhammad and A. M. Sani

101. Impact of acute iron and copper intoxication on biochemical liver function in Wistar rat, Nadeem Sheikh, Afia Farrukh, Tasleem Akhtar and Kashif-ur-Rehman

105. MicroRNA as non-invasive biomarkers of breast cancer, Saima Sadaf, Jawaria Shaheen, Kanwal Shabir and M. Waheed Akhtar

61. Nutritional exploration of leaves, seed and fruit of bael (Aegle marmelos L.) grown in Karachi region Lakht-e-Zehra, Asadullah, Nabeela G. Dar, Nida Saleem, Umed Ali Soomro, Waqas Afzal, Beena Naqvi and Khalid Jamil

66. Kinetic parameters analysis and pH stability of protease from a thermophilic Bacillus species, Aysha Kamran and Zainab Bibi

69. Evaluation of prescribing trends and cost analysis of peptic ulcer disease regimen in tertiary care setting, Sehrish Lakhani, Rabia Bushra, Shazia Alam and Yousra Shafiq

74. Anxiolytic profile of tryptophan as monitored following repeated administration in male rats, Muhammad Farhan, Hamna Rafiq, Hira Rafi, Sajjad Haider Naqvi, Faizan ul Hassan Naqvi1, Darakshan J. Haleem

79. Mutational analysis of p53 gene in sporadic breast carcinoma, Rabia Bushra and Yousra Shafiq

27. Review Article: Regulation of alternative splicing and the case of Bcl-x, Lulzim Shkreta, Alexandre Cloutier, Johanne Toutant, Hervé Vennin Rendos and Benoit Chabot

39. Enhancement of memory following repeated administration of NSAIDs in rats, Shaista Emad, Sana Sadaf, Mohammad Misbah ur Rehman, Saida Haider and Tahira Perveen

43. Behavioral consequences of repeated fluoxetine administration in tryptophan pretreated albino wistar rats, Hira Awan, Sana Qadeer and Muhammad Farhan

48. Appraisal of nutritional status and in vitro mass propagation of sugarcane (saccharum officinarum l. Cv. Us-633) through callus culture, Muafia Shafique, Shaista Jabeen Khan and Nuzhat Habib Khan

53. Identification of cultivable bacteria from natural honey of different botanical origin, Saba Naseer, Shakeel Ahmed Khan and M. Kamran Azim

57. Genetic characterization of Scorias spongiosa identified in citrus: a first report from Pakistan, Riffat Batool, Ejaz Aziz, Sobia Kanwal, Hassan Javed Chaudhary, Syed Muhammad Saqlan Naqvi, Tariq Mahmood

1. Guest Editorial: Recent challenges of conducting biological research in Pakistan, Mohammad Perwaiz Iqbal

3. Effect of curcumin supplementation on antioxidant enzymes in liver cirrhosis: study in rats, Syeda Nuzhat Fatima Zaidi and Tabassum Mahboob

7. Molecular cloning, sequence characterization and expression analysis of somatotropin gene of an indigenous chicken breed (Aseel), Saima Sadaf, Monazza Rasheed, Romana Sarwar, Samina Kausarand M. Waheed Akhtar

15. Screening and enhanced production of protease from a thermophilic Bacillus species, Aysha Kamran, Zainaib Bibi and Mustufa Kamal

18. Antibacterial activity of natural honey against antibiotic-resistant bacteria, M. Aurongzeb and M. Kamran Azim

22. Effect of mRNA secondary structure on expression level of catalytic domain of XynI from Caldicellulosiruptor saccharolyticus DSM 8903 in E. coli, Saher Shahid, Razia Tajwar and M. Waheed Akhtar